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desvenlafaxine will increase the stage or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, 400 mg) lower the CYP2D6 substrate dose by around 50%; no dosage adjustment essential with desvenlafaxine doses seven consecutive times straight away